Insulin Resistance would be bad for you!

insulin resistance

Man are always looking to better they in any field since it would help them to get a better result ad understanding.  Nothing is done right the first time, so innovation is always good.  As such, insulin resistance is one risk factor among diabetics because this is the time when the insulin is no longer effective.  Insulin is the substance that helps people who suffers from diabetes to regulate spike of blood sugar.  When insulin is no longer effective, it would be harder to control diabetes.

The only possible way to control diabetes to implement a higher dose of insulin or get a new drug that you’re diabetician would recommend to you. Unfortunately, the introduction of insulin to the body has a side effect and as such would result to a bigger you and other health problems.

Fortunately, Dr. Domenico Accili — director of the Columbia University Diabetes Research Center at Columbia University Medical Center in New York City, NY — and colleagues have found out that there a few compounds that may be just as effective as current insulin resistance medications on the market, but which would not let you get fat in the process. The said research is reported in the Journal Cell.

Insulin Resistance

You might want to know more about weight gain and the reason behind it all. It has something to do with the protein known as FOX01. Such inhibitor limited the production of the glucose in the liver.  That is why, there are less glucose in the body that can control diabetes.

“Thus, treatment of insulin resistance with a broadly acting FOXO1 inhibitor can lead to a host of unwanted side effects, such as weight gain,” says Dr. Accili. “Unfortunately, with FOXO1 insulin sensitizers, you get the good with the bad.”

Researchers are looking for a way to block FOXO1 without influencing lipid production and are not able to find the way to do just that. Dr. Accili and colleagues’ uses mice to find the solution. They aimed to unravel the mechanisms by which FOXO1 regulates glucose production in the liver, and how this differs to the way the protein controls lipid production.  Throughout research, they found out that the best way to do that is to introduce a new protein called SIN3A to the FOX01.

“This suggested that if we could find molecules that act on the glucose-production arm of FOXO1 while leaving SIN3A alone,” explains Dr. Accili, “we could improve insulin sensitivity and lower blood sugar without increasing fat.”